Leftward asymmetry in relative ¢ber density of the arcuate fasciculus

نویسندگان

  • Paolo G. P. Nucifora
  • Ragini Verma
  • Elias R. Melhem
  • Raquel E. Gur
  • Ruben C. Gur
چکیده

Left hemispheric language dominance is well established, but the structural substrate for this functional asymmetry is uncertain. We report a strong asymmetry in the relative ¢ber density of the arcuate fasciculus, a white matter pathway associated with language that connects the frontal, temporal, andparietal lobes.Measured with di¡usion tensor tractography, nearly all study participants demonstrated greater relative ¢ber density in the left arcuate fasciculus than in the right arcuate fasciculus. In comparison, we found no asymmetry in the corticospinal tract, an important white matter pathway with no known role in language. Combined with data on volumetric and activation asymmetry, greater connectivity may provide the elements of a neural system model for language lateralization. NeuroReport 00:000^000 c 2005 Lippincott Williams &Wilkins.

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تاریخ انتشار 2005